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Case Study: ARUP Laboratories and Ingenuity Variant Analysis


This case study of ARUP Laboratories is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service.

“[Ingenuity Variant Analysis] provides easy access to excellent gene variant interpretation, especially for those without a bioinformatics background. It has also greatly reduced the time from variant call to seeing “final” results.”


  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Improved access to biological content including primary sources
    • Reduced the need for developing own informatics pipeline
    • Eliminated the need for creating and maintaining own up-to-date database of biomedical literature
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Access rich biological content in Ingenuity Knowledge Base plus additional sources of variant level content
    • Increase trust in the insights received from experiment
    • Access user friendly interface and no bioinformatics experience needed
    • Collaborate and share easily with colleagues and peers

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Genome
    • DNA sequencing – Whole Exome
    • DNA sequencing – Targeted / Gene Panel
  • Sequencing data is from the following platforms:
    • Illumina MiSeq
    • Illumina Genome Analyzer (GA) / HiSeq
    • Ion Torrent PGM
    • Complete Genomics


  • Chose Ingenuity Systems over the following solutions:
    • Cartagenia
    • Knome
    • VAAST / Omicia
    • In-house developed software
  • Saves 1 to 3 days per sample using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Reduced time to results by 10 to 49% by using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Speed: 5 (strongly differentiated)
    • Accurate evidence: 4 (very differentiated)
    • Accessibility/ ease of use: 4 (very differentiated)
    • Sharing with colleagues/peers: 5 (strongly differentiated)
  • Is very satisfied with the ease of use of Ingenuity Variant Analysis.

About This Data

This data was sourced directly from verified users of QIAGEN Digital Insights by TechValidate.

TechValidate verifies the identity and organizational affiliation of all participants that contribute to published research data. When research participants so desire, we also guarantee their anonymity so that they may share information honestly and freely.

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