TechValidate Research on QIAGEN Digital Insights

23 Case Studies


PowerSoil Pro Case Study

Cal Poly San Luis Obispo

Introduction

This case study of Cal Poly San Luis Obispo is based on a February 2019 survey of PowerSoil Pro customers by TechValidate, a 3rd-party research service.

“I am planning to switch to the DNeasy PowerSoil Pro Kit for future projects.”

Challenges

The business challenges that led the profiled organization to evaluate and ultimately select DNeasy PowerSoil Pro:

  • Before trying the DNeasy PowerSoil Pro, they typically used Zymo to isolate DNA from soil
  • When isolating DNA using Zymo, they faced challenges with the following:
    • Difficult to lyse the microbes in a sample

Use Case

The key features and functionalities of DNeasy PowerSoil Pro that the surveyed organization uses:

  • Tested soil with the DNeasy PowerSoil Pro Kit.
  • Their application downstream of DNA isolation:
    • 16S or ITS sequencing

Results

The surveyed organization achieved the following results with DNeasy PowerSoil Pro:

  • How the DNeasy PowerSoil Pro Kit solved their problems:
    • Faster protocol
    • Easier protocol

Case Study: Medical Institution and Ingenuity Variant Analysis for Ion Reporter

Introduction

This case study of a educational institution is based on a April 2014 survey of Ingenuity Variant Analysis plugin for Ion Reporter customers by TechValidate, a 3rd-party research service. The profiled organization asked to have their name blinded to protect their confidentiality.

“Fast identification of variants in sequencing study; free preview!”

Challenges

  • Tried the Ingenuity Variant Analysis plugin for Ion Reporter because of a referral by an employee of Life Technologies or Ingenuity.
  • Addresses the following challenges in Ion Reporter with the Ingenuity Variant Analysis plugin:
    • Ease of use / usability
    • Sharing work with colleagues

Use Case

  • Has 2-5 people in their lab using the Ingenuity Variant Analysis Plugin for Ion Reporter.
  • Is using for Ion Reporter for Exome / Genome sample types.

Results

  • Helped reduce time to generate a short list of interesting variants with the Ingenuity Variant Analysis plugin for Ion Reporter.
  • Accessed findings from biomedical literature by using the Ingenuity Variant Analysis plugin for Ion Reporter.
  • The following differentiates the Ingenuity Variant Analysis plugin for Ion Reporter from competitive products:
    • Scientific credibility
    • Speed of access to application

Case Study: Large Health Care Company and Ingenuity Variant Analysis for Ion Reporter

Introduction

This case study of a large enterprise health care company is based on a April 2014 survey of Ingenuity Variant Analysis plugin for Ion Reporter customers by TechValidate, a 3rd-party research service. The profiled company asked to have their name blinded to protect their confidentiality.

Challenges

  • Tried the Ingenuity Variant Analysis plugin for Ion Reporter because of the ease of accessing within Ion Reporter.
  • Addresses the challenge of accessing complete biological annotation in Ion Reporter.

Use Case

  • Is using Ingenuity Variant Analysis plugin for Ion Reporter for Gene Panel sample types to determine driver mutations in oncology samples.

Results

  • Helped reduce time to generate a short list of interesting variants with the Ingenuity Variant Analysis plugin for Ion Reporter.
  • Received the following scientific benefits:
    • Performed causal network analysis to identify relevant variants in genes
    • Accessed findings from biomedical literature
  • Speed of access to the application differentiates the Ingenuity Variant Analysis plugin for Ion Reporter from competitive products.

Case Study: Non Profit Research Institute and Ingenuity Variant Analysis for Ion Reporter

Introduction

This case study of a non-profit is based on a April 2014 survey of Ingenuity Variant Analysis plugin for Ion Reporter customers by TechValidate, a 3rd-party research service. The profiled organization asked to have their name blinded to protect their confidentiality.

“We can simply output the annotated variant list with AA, Nuc, MAF etc making it easy to get to your variants of interest without any expertise needed.”

Challenges

  • Tried the Ingenuity Variant Analysis plugin for Ion Reporter because of easy to access within Ion Reporter.
  • Addresses the following challenges in Ion Reporter:
    • additional annotation

Use Case

  • Has 2-5 people in their lab using the Ingenuity Variant Analysis Plugin for Ion Reporter.
  • Is using for Gene Panel sample types.

Results

  • Achieved the following with the Ingenuity Variant Analysis plugin for Ion Reporter:
    • Helped reduce time to generate a short list of interesting variants
    • Increased efficiency and team productivity
  • Received the following scientific benefits:
    • Performed causal network analysis to identify relevant variants in genes
    • Quickly identified new findings
  • The following differentiates from competitive products:
    • Speed of access to application
    • Flexibility
    • Ability to customize analysis

Case Study: Educational Institution and Ingenuity Variant Analysis for Ion Reporter

Introduction

This case study of a educational institution is based on a April 2014 survey of Ingenuity Variant Analysis plugin for Ion Reporter customers by TechValidate, a 3rd-party research service. The profiled organization asked to have their name blinded to protect their confidentiality.

“Fantastic software to identify SNVs!”

Challenges

  • Tried the Ingenuity Variant Analysis plugin for Ion Reporter because of Ingenuity’s reputation for high quality products.
  • Addresses the following challenges:
    • Ease of use / usability
    • Access to complete biological annotation
    • Sharing work with colleagues

Use Case

  • Has 2-5 people in their lab using the Ingenuity Variant Analysis Plugin for Ion Reporter.
  • Is using for Gene Panel sample types.

Results

  • Achieved the following with the Ingenuity Variant Analysis plugin for Ion Reporter:
    • Helped reduce time to generate a short list of interesting variants
    • Increased access to rich biological content
    • Increased efficiency and team productivity
    • Enabled improved sharing and collaboration
  • Received the following scientific benefits:
    • Performed causal network analysis to identify relevant variants in genes
    • Accessed findings from biomedical literature
    • Quickly identified new findings
  • The following differentiates from competitive products:
    • Scientific credibility
    • Value for price
    • Speed of access to application

Case Study: GeniaGeo and Ingenuity Variant Analysis for Ion Reporter

Introduction

This case study of GeniaGeo is based on a April 2014 survey of Ingenuity Variant Analysis plugin for Ion Reporter customers by TechValidate, a 3rd-party research service.

“It does simplify our work, and it’s essential to identify deleterious variants. Thanks to Ingenuity.”

Challenges

  • Tried the Ingenuity Variant Analysis plugin for Ion Reporter because of a need for additional tools for biological analysis and interpretation.
  • Addresses the challenge of accessing complete biological annotations in Ion Reporter

Use Case

  • Is using Ingenuity Variant Analysis plugin for Ion Reporter for Gene Panel sample types.

Results

  • Helped reduce time to generate a short list of interesting variants with the Ingenuity Variant Analysis plugin for Ion Reporter:
  • Scientific benefits included both quickly confirming prior findings and identifying new findings
  • Sees the Ingenuity Variant Analysis plugin for Ion Reporter differentiated from competitive products in terms of:
    • Scientific credibility
    • Value for price
    • Speed of access to application

Case Study: Educational Institution

Introduction

This case study of a educational institution is based on a July 2013 survey of Ingenuity IPA customers by TechValidate, a 3rd-party research service. The profiled organization asked to have their name blinded to protect their confidentiality.

“I appreciate the insight from IPA analysis, especially from upstream regulator analysis.”

Challenges

  • Solved the following challenges since deploying IPA for RNA sequencing analysis:
    • Can now distinguish different isoforms
  • Purchased IPA for RNA sequencing analysis for the following reasons:
    • Interpret the impact of expression changes in the context of biological processes, disease and cellular phenotypes, and molecular interactions
    • Compile targeted bibliographies with experimental evidence linking their differentially expressed isoforms to biological processes, disease, and molecular interactions

Use Case

  • Uses the following species in their RNA seq analysis:
    • Humans
    • Mice
  • Uses the following upstream analysis packages to generate RNA-Seq expression values:
    • Use R and perl

Results

  • Purchased IPA for RNA seq analysis over the following competitors:
    • In-house developed software
  • Rates the following IPA capabilities compared to the competition:
    • Faster time to insights: highly differentiated
    • Ease of use: differentiated
    • Novel insights: highly differentiated
    • Deeper analysis: highly differentiated
  • Saved 1 to 3 days per analysis with IPA for their RNA seq analysis.
  • Is very satisfied with the value for identifying biologically relevant isoforms from RNA seq data using IPA.
  • Increased the productivity of their bioinformatics staff for RNA seq analysis by 2 to 5x with IPA.

Case Study: State and Local Government

Introduction

This case study of CRP-Sante is based on a July 2013 survey of Ingenuity IPA customers by TechValidate, a 3rd-party research service.

“IPA provides access to functional annotation of high throughput data in an easy way.”

Challenges

  • Solved the following challenges since deploying IPA for RNA sequencing analysis:
    • Improved precise measurement of transcripts
    • Can now distinguish different isoforms
  • Purchased IPA for RNA sequencing analysis for the following reasons:
    • Interpret the impact of expression changes in the context of biological processes, disease and cellular phenotypes, and molecular interactions
    • Compile targeted bibliographies with experimental evidence linking their differentially expressed isoforms to biological processes, disease, and molecular interactions

Use Case

  • Uses the following species in their RNA seq analysis:
    • Humans
  • Uses the following upstream analysis packages to generate RNA-Seq expression values:
    • Cufflinks/Cuffdiff
    • DESeq
    • EdgeR
    • Partek

Results

  • Purchased IPA for RNA seq analysis over the following competitors:
    • GeneGo
  • Rates the following IPA capabilities compared to the competition:
    • Ease of use: highly differentiated
  • Is satisfied with the value for identifying biologically relevant isoforms from RNA seq data using IPA.

Case Study: Semmelweis University

Introduction

This case study of Semmelweis University is based on a July 2013 survey of Ingenuity IPA customers by TechValidate, a 3rd-party research service.

“[IPA provides] complex, integrated analysis, pathway analysis, and super visualization.”

Challenges

  • Solved the following challenges since deploying IPA for RNA sequencing analysis:
    • Improved understanding of the structure of different isoforms
    • Improved precise measurement of transcripts
    • Can now distinguish different isoforms
    • Can more clearly identify biologically relevant isoforms
  • Purchased IPA for RNA sequencing analysis for the following reasons:
    • Interpret the impact of expression changes in the context of biological processes, disease and cellular phenotypes, and molecular interactions

Use Case

  • Uses the following species in their RNA seq analysis:
    • Humans
  • Uses the following upstream analysis packages to generate RNA-Seq expression values:
    • CLC bio

Results

  • Purchased IPA for RNA seq analysis over the following competitors:
    • In-house developed software
    • CLC Genomic Workbench
  • Rates the following IPA capabilities compared to the competition:
    • Faster time to insights: differentiated
    • Ease of use: differentiated

Case Study: Educational Institution

Introduction

This case study of a educational institution is based on a July 2013 survey of Ingenuity IPA customers by TechValidate, a 3rd-party research service. The profiled organization asked to have their name blinded to protect their confidentiality.

“IPA is very useful and has become a daily tool of my research.”

Challenges

  • Solved the following challenges since deploying IPA for RNA sequencing analysis:
    • Improved understanding of the structure of different isoforms
    • Can now distinguish different isoforms
    • Can more clearly identify biologically relevant isoforms
  • Purchased IPA for RNA sequencing analysis for the following reasons:
    • Interpret the impact of expression changes in the context of biological processes, disease and cellular phenotypes, and molecular interactions
    • Compile targeted bibliographies with experimental evidence linking their differentially expressed isoforms to biological processes, disease, and molecular interactions

Use Case

  • Uses the following species in their RNA seq analysis:
    • Humans
    • Mice
  • Uses the following upstream analysis packages to generate RNA-Seq expression values:
    • EdgeR

Results

  • Purchased IPA for RNA seq analysis over the following competitors:
    • GeneGo
  • Rates the following IPA capabilities compared to the competition:
    • Faster time to insights: extremely differentiated
    • Ease of use: extremely differentiated
    • Novel insights: extremely differentiated
    • Deeper analysis: extremely differentiated
  • Is extremely satisfied with the value for identifying biologically relevant isoforms from RNA seq data using IPA.

Case Study: The University Of Texas At Austin

Introduction

This case study of The University of Texas at Austin is based on a July 2013 survey of Ingenuity IPA customers by TechValidate, a 3rd-party research service.

“IPA has deepened my understanding of a critical RNA helicase and its plethora of cellular connections to cancer. It has given to me a year’s worth of knowledge in a weekend’s time.”

Challenges

  • Solved the following challenges since deploying IPA for RNA sequencing analysis:
    • Improved precise measurement of transcripts
    • Can more clearly identify biologically relevant isoforms
  • Purchased IPA for RNA sequencing analysis for the following reasons:
    • Interpret the impact of expression changes in the context of biological processes, disease and cellular phenotypes, and molecular interactions
    • Visualize their RNA seq data in context of Isoform View

Use Case

  • Uses the following species in their RNA seq analysis:
    • Humans
  • Uses the following upstream analysis packages to generate RNA-Seq expression values:
    • DESeq
    • Bioconductor

Results

  • Rates the following IPA capabilities compared to the competition:
    • Faster time to insights: extremely differentiated
    • Ease of use: extremely differentiated
    • Novel insights: extremely differentiated
    • Deeper analysis: extremely differentiated
  • Saved > 3 days per analysis with IPA for their RNA seq analysis.
  • Is extremely satisfied with the value for identifying biologically relevant isoforms from RNA seq data using IPA.
  • Increased the productivity of their bioinformatics staff for RNA seq analysis by > 10x with IPA.

Case Study: Primary Investigator at an Educational Institution

Introduction

This case study of a educational institution is based on a July 2013 survey of Ingenuity IPA customers by TechValidate, a 3rd-party research service. The profiled organization asked to have their name blinded to protect their confidentiality.

“IPA is easy to use for every researcher including wet-bench researchers.”

Challenges

  • Solved the following challenges since deploying IPA for RNA sequencing analysis:
    • Can more clearly identify biologically relevant isoforms
  • Purchased IPA for RNA sequencing analysis for the following reason:
    • Quickly identify differentially expressed isoforms

Use Case

  • Uses the following species in their RNA seq analysis:
    • Humans
    • Mice
  • Uses the following upstream analysis packages to generate RNA-Seq expression values:
    • Cufflinks/Cuffdiff
    • DESeq
    • EdgeR
    • Bioconductor

Results

  • Purchased IPA for RNA seq analysis over the following competitor:
    • In-house development software
  • Rates the following IPA capabilities compared to the competition:
    • Faster time to insights: highly differentiated
    • Ease of use: highly differentiated
    • Novel insights: differentiated
    • Deeper analysis: highly differentiated
  • Saved 4 to 8 hours per analysis with IPA for their RNA seq analysis.
  • Is very satisfied with the value for identifying biologically relevant isoforms from RNA seq data using IPA.
  • Increased the productivity of their bioinformatics staff for RNA seq analysis by 5 to 10x with IPA.

Case Study: Educational Institution

Introduction

This case study of a educational institution is based on a August 2013 survey of Ingenuity IPA customers by TechValidate, a 3rd-party research service. The profiled organization asked to have their name blinded to protect their confidentiality.

“IPA has the deepest database and is the easiest to use compared to anything else on the market. The ‘Upstream Regulator’ function is unique to IPA and is one of the main reasons I use this bioinformatic software.”

Challenges

  • Solved the following challenges since deploying IPA for RNA sequencing analysis:
    • Improved precise measurement of transcripts
  • Purchased IPA for RNA sequencing analysis for the following reasons:
    • Interpret the impact of expression changes in the context of biological processes, disease and cellular phenotypes, and molecular interactions
    • Compile targeted bibliographies with experimental evidence linking their differentially expressed isoforms to biological processes, disease, and molecular interactions

Use Case

  • Uses the following species in their RNA seq analysis:
    • Humans
  • Uses the following upstream analysis packages to generate RNA-Seq expression values:
    • DESeq
    • Partek

Results

  • Rates the following IPA capabilities compared to the competition:
    • Faster time to insights: highly differentiated
    • Ease of use: highly differentiated
    • Novel insights: extremely differentiated
    • Deeper analysis: extremely differentiated
  • Is very satisfied with the value for identifying biologically relevant isoforms from RNA seq data using IPA.
  • Increased the productivity of their bioinformatics staff for RNA seq analysis by 5 to 10x with IPA.

Case Study: Academic Research Institution and Ingenuity Variant Analysis

Introduction

This case study of a educational institution is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service. The profiled organization asked to have their name blinded to protect their confidentiality.

“Through the use of Ingenuity we are now able to quickly and efficiently analyze our data and share the results with our collaborators.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Reduced the need for developing own informatics pipeline
    • Enabled support for more studies by providing a self-service tool for colleagues and collaborators
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Reduce time to identify variants worth following up on
    • Identify high impact, most compelling variants to follow up on
    • Access user friendly interface and no bioinformatics experience needed
    • Collaborate and share easily with colleagues and peers

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Exome
    • DNA sequencing – Targeted / Gene Panel
  • Sequencing data is from the following platforms:
    • Illumina Genome Analyzer (GA) / HiSeq
    • Life Technologies SOLiD

Results

  • Chose Ingenuity Systems over the following solutions:
    • In-house developed software
  • Saves 1 to 3 days per sample using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Speed: 3 (differentiated)
    • Accessibility/ ease of use: 4 (very differentiated)
    • Sharing with colleagues/peers: 5 (strongly differentiated)
    • Security: 4 (very differentiated)
  • Is satisfied with the ease of use of Ingenuity Variant Analysis.

Case Study: Large Private Cancer Center and Ingenuity Variant Analysis

Introduction

This case study of a large enterprise health care company is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service. The profiled company asked to have their name blinded to protect their confidentiality.

“From an operational standpoint, Ingenuity has made the analysis of shared samples by researchers of varying levels of expertise much easier.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Improved sharing and collaboration capabilities
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Identify high impact, most compelling variants to follow up on
    • Access user friendly interface and no bioinformatics experience needed
    • Secure web application that is HIPAA and Safe Harbor compliant

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Genome
    • DNA sequencing – Whole Exome
  • Sequencing data is from the following platforms:
    • Illumina Genome Analyzer (GA) / HiSeq
    • Complete Genomics

Results

  • Chose Ingenuity Systems over the following solutions:
    • In-house developed software
  • Reduced time to results by > 75% by using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Speed: 5 (strongly differentiated)
    • Accurate evidence: 3 (differentiated)
    • Accessibility/ ease of use: 4 (very differentiated)
    • Sharing with colleagues/peers: 5 (strongly differentiated)
    • Security: 4 (very differentiated)
  • Is satisfied with the ease of use of Ingenuity Variant Analysis.

Case Study: Educational Institution and Ingenuity Variant Analysis

Introduction

This case study of a educational institution is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service. The profiled organization asked to have their name blinded to protect their confidentiality.

“Ingenuity Variant Analysis has massively reduced the time it takes to filter variants for prioritization. I can do any type of filtering I like while using the same computational protocol in an intuitive, user friendly interface.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Reduced IT infrastructure costs
    • Improved access to biological content including primary sources
    • Improved sharing and collaboration capabilities
    • Reduced the need for developing own informatics pipeline
    • Eliminated the need for creating and maintaining own up-to-date database of biomedical literature
    • Enabled independent study without the need for specialized bioinformatics skills
    • Enabled support for more studies by providing a self-service tool for colleagues and collaborators
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Access rich biological content in Ingenuity Knowledge Base plus additional sources of variant level content
    • Reduce time to identify variants worth following up on
    • Identify high impact, most compelling variants to follow up on
    • Access user friendly interface and no bioinformatics experience needed
    • Secure web application that is HIPAA and Safe Harbor compliant
    • Scale from small to large studies
    • Collaborate and share easily with colleagues and peers

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Genome
    • DNA sequencing – Whole Exome
  • Sequencing data is from the following platforms:
    • Illumina Genome Analyzer (GA) / HiSeq
    • Complete Genomics

Results

  • Chose Ingenuity Systems over the following solutions:
    • In-house developed software
  • Saves > 3 days per sample using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Reduced time to results by > 75% by using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Speed: 5 (strongly differentiated)
    • Accurate evidence: 3 (differentiated)
    • Accessibility/ ease of use: 5 (strongly differentiated)
    • Sharing with colleagues/peers: 5 (strongly differentiated)
  • Is extremely satisfied with the ease of use of Ingenuity Variant Analysis.

Case Study: Small Pharmaceutical Company and Ingenuity Variant Analysis

Introduction

This case study of a small business pharmaceuticals company is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service. The profiled company asked to have their name blinded to protect their confidentiality.

“The Ingenuity Variant Analysis platform allowed us to start analyzing our samples faster than building our own informatics pipeline. It also made it easier to customize the analytical approach. The filter settings could be easily modified. Overall it made analysis easier and faster.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Reduced the need for developing own informatics pipeline
    • Enabled independent study without the need for specialized bioinformatics skills
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Reduce time to identify variants worth following up on

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Exome
    • Illumina Omni DNA Array
  • Sequencing data is from the following platforms:
    • Illumina Genome Analyzer (GA) / HiSeq
    • Illumina Omni DNA Array

Results

  • Chose Ingenuity Systems over the following solutions:
    • PLINK
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Speed: 5 (strongly differentiated)
    • Accessibility/ ease of use: 4 (very differentiated)
    • Sharing with colleagues/peers: 3 (differentiated)
    • Security: 3 (differentiated)
  • Is very satisfied with the ease of use of Ingenuity Variant Analysis.

Case Study: The University Of Chicago and Ingenuity Variant Analysis

Introduction

This case study of The University of Chicago is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service.

“[Ingenuity Variant Analysis] streamlines the analysis for our whole exome studies on the etiology of diseases.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Reduced IT infrastructure costs
    • Improved access to biological content including primary sources
    • Improved sharing and collaboration capabilities
    • Reduced the need for developing own informatics pipeline
    • Eliminated the need for creating and maintaining own up-to-date database of biomedical literature
    • Enabled independent study without the need for specialized bioinformatics skills
    • Enabled support for more studies by providing a self-service tool for colleagues and collaborators
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Access rich biological content in Ingenuity Knowledge Base plus additional sources of variant level content
    • Reduce time to identify variants worth following up on
    • Identify high impact, most compelling variants to follow up on
    • Access user friendly interface and no bioinformatics experience needed
    • Scale from small to large studies
    • Collaborate and share easily with colleagues and peers

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Exome
  • Sequencing data is from the following platforms:
    • Illumina MiSeq

Results

  • Chose Ingenuity Systems over the following solutions:
    • In-house developed software
  • Saves 1 to 3 days per sample using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Reduced time to results by > 75% by using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Speed: 5 (strongly differentiated)
    • Accurate evidence: 5 (strongly differentiated)
    • Accessibility/ ease of use: 5 (strongly differentiated)
    • Sharing with colleagues/peers: 5 (strongly differentiated)
    • Security: 3 (differentiated)
  • Is extremely satisfied with the ease of use of Ingenuity Variant Analysis.

Case Study: Harvard University and Ingenuity Variant Analysis

Introduction

This case study of Harvard University is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service.

“[Ingenuity Variant Analysis] helped provide clarity, confirmation and graphic visualization of our analysis results.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Reduced IT infrastructure costs
    • Improved access to biological content including primary sources
    • Improved sharing and collaboration capabilities
    • Reduced the need for developing own informatics pipeline
    • Eliminated the need for creating and maintaining own up-to-date database of biomedical literature
    • Enabled independent study without the need for specialized bioinformatics skills
    • Enabled support for more studies by providing a self-service tool for colleagues and collaborators
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Access rich biological content in Ingenuity Knowledge Base plus additional sources of variant level content
    • Reduce time to identify variants worth following up on
    • Identify high impact, most compelling variants to follow up on
    • Access user friendly interface and no bioinformatics experience needed
    • Collaborate and share easily with colleagues and peers

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • Gene Pathway Analysis
  • Sequencing data is from the following platforms:
    • Illumina MiSeq

Results

  • Reduced time to results by > 75% by using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Accessibility/ ease of use: 3 (differentiated)
    • Speed: 4 (very differentiated)
  • Is satisfied with the ease of use of Ingenuity Variant Analysis.

Case Study: Governmental Research Institute and Ingenuity Variant Analysis

Introduction

This case study of National Institutes of Health is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service.

“The biggest advantage of Ingenuity compared to other tools is that it is very user-friendly and very fast. I have bioinformatics skills, but it is very easy and convenient to use and share with colleagues who have none. Also, I love the fact that pathways and biological knowledge from genes and diseases are integrated in this tool.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Improved access to biological content including primary sources
    • Enabled independent study without the need for specialized bioinformatics skills
    • Enabled support for more studies by providing a self-service tool for colleagues and collaborators
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Access rich biological content in Ingenuity Knowledge Base plus additional sources of variant level content
    • Reduce time to identify variants worth following up on
    • Identify high impact, most compelling variants to follow up on

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Exome
  • Sequencing data is from the following platforms:
    • Illumina Genome Analyzer (GA) / HiSeq

Results

  • Chose Ingenuity Systems over the following solutions:
    • ANNOVAR
  • Saves > 3 days per sample using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Reduced time to results by 50 to 74% by using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Speed: 5 (strongly differentiated)
    • Accessibility/ ease of use: 5 (strongly differentiated)
    • Sharing with colleagues/peers: 5 (strongly differentiated)
  • Is extremely satisfied with the ease of use of Ingenuity Variant Analysis.

Case Study: Cornell University and Ingenuity Variant Analysis

Introduction

This case study of Cornell University is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service.

“Identifying the causal variants supported by high confidence literature is the key thing in which our institute is interested. Ingenuity makes it so simple and easy. [Our] thanks to Ingenuity.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Improved access to biological content including primary sources
    • Improved sharing and collaboration capabilities
    • Eliminated the need for creating and maintaining own up-to-date database of biomedical literature
    • Enabled support for more studies by providing a self-service tool for colleagues and collaborators
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Access rich biological content in Ingenuity Knowledge Base plus additional sources of variant level content
    • Reduce time to identify variants worth following up on
    • Identify high impact, most compelling variants to follow up on
    • Collaborate and share easily with colleagues and peers

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Genome
  • Sequencing data is from the following platforms:
    • Illumina Genome Analyzer (GA) / HiSeq

Results

  • Chose Ingenuity Systems over the following solutions:
    • ANNOVAR
    • VAAST / Omicia
  • Saves > 3 days per sample using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Reduced time to results by > 75% by using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Speed: 5 (strongly differentiated)
    • Accurate evidence: 5 (strongly differentiated)
    • Accessibility/ ease of use: 5 (strongly differentiated)
    • Sharing with colleagues/peers: 5 (strongly differentiated)
    • Security: 5 (strongly differentiated)
  • Is extremely satisfied with the ease of use of Ingenuity Variant Analysis.

Case Study: QIMR and Ingenuity Variant Analysis

Introduction

This case study of QIMR is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service.

“[The] reduced reliance on our bioinformatics team allows for faster turn around for us, and thus greater availability of that team for other projects. The findings link to the supporting literature, which assists in identifying all the evidence that may otherwise have been missed.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Improved access to biological content including primary sources
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Access rich biological content in Ingenuity Knowledge Base plus additional sources of variant level content
    • Reduce time to identify variants worth following up on

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Exome
    • DNA sequencing – Targeted / Gene Panel
  • Sequencing data is from the following platforms:
    • Illumina Genome Analyzer (GA) / HiSeq
    • Ion Torrent PGM
    • Complete Genomics

Results

  • Chose Ingenuity Systems over the following solutions:
    • In-house developed software
  • Saves 4 to 8 hours per sample using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Reduced time to results by 50 to 74% by using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Accurate evidence: 4 (very differentiated)
    • Accessibility/ ease of use: 5 (strongly differentiated)
    • Sharing with colleagues/peers: 3 (differentiated)
  • Is extremely satisfied with the ease of use of Ingenuity Variant Analysis.

Case Study: ARUP Laboratories and Ingenuity Variant Analysis

Introduction

This case study of ARUP Laboratories is based on a March 2013 survey of Ingenuity Systems customers by TechValidate, a 3rd-party research service.

“[Ingenuity Variant Analysis] provides easy access to excellent gene variant interpretation, especially for those without a bioinformatics background. It has also greatly reduced the time from variant call to seeing “final” results.”

Challenges

  • Solved the following challenges by deploying Ingenuity Variant Analysis:
    • Realized faster and easier identification of causal variants
    • Improved access to biological content including primary sources
    • Reduced the need for developing own informatics pipeline
    • Eliminated the need for creating and maintaining own up-to-date database of biomedical literature
  • Purchased Ingenuity Variant Analysis for the following reasons:
    • Access rich biological content in Ingenuity Knowledge Base plus additional sources of variant level content
    • Increase trust in the insights received from experiment
    • Access user friendly interface and no bioinformatics experience needed
    • Collaborate and share easily with colleagues and peers

Use Case

  • Uses the following applications with Ingenuity Variant Analysis:
    • DNA sequencing – Whole Genome
    • DNA sequencing – Whole Exome
    • DNA sequencing – Targeted / Gene Panel
  • Sequencing data is from the following platforms:
    • Illumina MiSeq
    • Illumina Genome Analyzer (GA) / HiSeq
    • Ion Torrent PGM
    • Complete Genomics

Results

  • Chose Ingenuity Systems over the following solutions:
    • ANNOVAR
    • Cartagenia
    • Knome
    • VAAST / Omicia
    • In-house developed software
  • Saves 1 to 3 days per sample using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Reduced time to results by 10 to 49% by using Ingenuity Variant Analysis for DNA variant annotation and analysis.
  • Rated the following Ingenuity Variant Analysis capabilities in terms of how differentiated they are compared to other data analysis solutions:
    • Speed: 5 (strongly differentiated)
    • Accurate evidence: 4 (very differentiated)
    • Accessibility/ ease of use: 4 (very differentiated)
    • Sharing with colleagues/peers: 5 (strongly differentiated)
  • Is very satisfied with the ease of use of Ingenuity Variant Analysis.



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